The vast majority of cancer deaths are due to metastatic disease. While various treatment options are available, chemotherapy prevails as the principle treatment especially in the case of highly aggressive and metastatic cancers. However, even though potent chemotherapeutic drugs are available to oncologists, the dose of these agents is constrained by their toxicity to normal tissue, because they are distributed within cancer and healthy tissues in a non-specific manner. Furthermore, metastases present unique challenges due to their smaller size, higher dispersion to organs, and lower vascularization than primary tumors, making them less accessible to therapeutic agents. To effectively seek and destroy metastases, we exploit nanotechnology to fabricate a 100-nm-long multi-component nanoparticle, called the nanochain. Due to the unique material properties that appear at the nano-scale, nanoparticles provide many potential benefits and new opportunities to address the complexity of metastatic cancer. The nanochain particle is made of different nanospheres connected one to another much like a stack of Legos. Specifically, we link three magnetic nanospheres made of iron oxide and one a lipid nanosphere filled with the drug. We then decorated the surface of the nanochain with multiple sites that bind with integrins. Integrins act as glue between the metastatic cancer cell and the lining of a blood vessel in the colonized organ. To home in on the cancer marker (integrin), we need a nanoparticle that would drift out of the central flow of the blood stream and to the blood vessel walls. The most common shape of nanoparticles is a sphere, but a sphere tends to go with the flow. However, due to its size and shape, the oblong nanochain tumbles out of the main current and skirts along vessel walls. Then, once the nanochain laches on one integrin binding site, others grab hold resulting in superior attachment of the nanochains onto metastases compared to spherical nanoparticles. A few hours later, after nanochains slip from the blood stream and congregate in metastases, a wire coil is placed, called a solenoid, outside near the body. Electricity passed through the solenoid creates a “mild” radiofrequency field (similar to frequencies of FM radio). The field causes the magnetic tails to vibrate, breaking open the liposome spheres. The application of radiofrequency facilitates rapid release of high amounts of free drug into metastatic tumors capable of spreading to deep regions of metastases, which are otherwise inaccessible by current drug delivery strategies. In animal studies, we found that this can result in at least 10 times greater cell death in metastatic tumors compared to traditional treatments.